E. Shatskikh1, E. Latypova1, V. Fisinin2, S. Denev3, P. Surai3-5*
Abstract. Commercial egg production is associated with various stresses decreasing productive and reproductive performance of layers. A growing body of evidence indicates that most of stresses in poultry production at the cellular level are associated with oxidative stress due to excess of free radical production or inadequate antioxidant protection. Recently, a concept of the cellular antioxidant defence has been revised with a special attention paid to cell signalling. Indeed, in animals, redox signalling pathways use reactive oxygen species (ROS) to transfer signals from different sources to the nucleus to regulate a number of various functions including growth, differentiation, proliferation and apoptosis. The vitagene concept of fighting stresses emerged as a new direction in a nutritional research. Indeed, by improving the adaptive ability of animals to stress it is possible tosubstantially decrease negative consequences of various stresses in poultry and farm animal production. The analysis of recently published data clearly showed that the anti-stress composition developed on the vitagene concept and supplied with drinking water is an effective means in fighting stresses in poultry production.