Pharmacokinetics of tilmicosin after oral application of Pulmotil G 200 – premix in pigs

Dimitrova, V. Katsarov, D. Dimitrov, D. Tsoneva
Abstract. The purpose of the present study was to determine the main pharmacokinetic parameters of tilmicosin after oral application of Pulmotil G 200-premix (Elanco). Eight clinically healthy Danube White pigs 4 from both genders, at the age of 9-10 weeks, weighing from 9 tо 14.55 kg were used. Pulmotil G 200- premix was applied once at a dose of 16 mg/kg body weight tilmicosin. Plasma antibiotic concentrations were assayed by HPLC and the main pharmacokinetic parameters of tilmicosin were calculated. The pharmacokinetic parameters of tilmicosin after application of Pulmotil G 200-premix were as followed: elimination half-life (t ) 14.92 0.87 h, maximum plasma concentrations (C ) 1.031 0.035 g/ml, time to reach maximum plasma concentrations (T ) 1/2 max max 2.096±0.095 h, area under the concentration-time curve (AUC ) 9.68±0.91 μg.h/ml. Plasma tilmicosin concentrations higher than 0.112±0.011 μg/ml → LOQ were detected for 24 hours while lower than 0.092 g/ml – until the end of the 72-h experimental period. The pharmacokinetic characteristics of tilmicosin after oral application to pigs corresponded to those specific for macrolide antibiotics and at the same time, was distinguished plasma concentrations maintained over a long period of time.

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