D. Dimitrova, P. Petkov, D. Tsoneva
Abstract. The aim of this investigation was determination of main pharmacokinetic parameters of tilmicosin after single subcutaneous application of Tilmovet solutio pro imjectionibus 30 % (Biovet LTD Peshtera). Tilmovet solutio pro imjectionibus 30 % was applied subcutaneously, as a 10 mg/kg dose, to 8 (4 male and 4 female, Brown Bulgarian breed) clinically healthy calves, aged 1.5 – months, weighing 71.5 to 91 kg. Blood plasma tilmicosin concentrations were assayed by HPLC. The main pharmacokinetic parameters were calculated. Pharmacokinetic parameters (mean ± SEM) of tilmicosin were as followed: t – 1/2β 32.33 ± 0.99 h, C – 0.976 ± 0.06 μg/mL, T – 1.00 ± 0.00 h, AUC h–18.22 ± 1.23 g.h/mL. Plasma tilmicosin concentrations higher than 0.1 ±0.009 max max 0→72 μg/mL were detected over the entire 72-hour period of observation after the s.c. application.