Dimitrova, V. Katsarov, D. Dimitrov, D. Tsoneva
Abstract. The purpose of the present study was to determine the main pharmacokinetic parameters of tilmicosin after oral application of Pulmotil G 200-premix (Elanco). Eight clinically healthy Danube White pigs 4 from both genders, at the age of 9-10 weeks, weighing from 9 tо 14.55 kg were used. Pulmotil G 200- premix was applied once at a dose of 16 mg/kg body weight tilmicosin. Plasma antibiotic concentrations were assayed by HPLC and the main pharmacokinetic parameters of tilmicosin were calculated. The pharmacokinetic parameters of tilmicosin after application of Pulmotil G 200-premix were as followed: elimination half-life (t ) 14.92 0.87 h, maximum plasma concentrations (C ) 1.031 0.035 g/ml, time to reach maximum plasma concentrations (T ) 1/2 max max 2.096±0.095 h, area under the concentration-time curve (AUC ) 9.68±0.91 μg.h/ml. Plasma tilmicosin concentrations higher than 0.112±0.011 μg/ml → LOQ were detected for 24 hours while lower than 0.092 g/ml – until the end of the 72-h experimental period. The pharmacokinetic characteristics of tilmicosin after oral application to pigs corresponded to those specific for macrolide antibiotics and at the same time, was distinguished plasma concentrations maintained over a long period of time.